Configure client side deduplication

Hi, our master server is NBU 7.6.0.3. It is also the only media server. There are no other media servers. We have a few clients which are all Windows clients to back up. The backup LAN is only 100MB/s. We are thinking to use client side deduplication on all the clients. 

I did some research and found the link below:

http://www.symantec.com/business/support/index?pag...

It seems there are a few configurations need to be done and some are optional. 

My question is:

What is the best practise for client side deduplicaiton? When shall we do those optional configurations?

Thanks in advance.